21 is the sum of 1+2+3+4+5+6. You could give 1 bottle of wine, 2 socks, 3 books, 4 coasters, 5 dollars and a 6 pack of beer.
21 is the atomic number for scandium. It is found in some sports equipment like baseball bats, lacrosse sticks and bicycle frames so these could work into the theme.
21 is the legal drinking age in some places. If that’s the case for you giftee, think about taking them for a beer.
Blackjack, also known as ‘21’, is one of the most popular casino games. Since you can gamble at age 21, why not take your giftee to play a few rounds? Or just play some cards at home.
There were many inventions and scientific advances in the 21st century. Try incorporating one of them into your gift (eg: any bluetooth equipped item, a smart phone).
Check out our general birthday theme for more ideas around gifts, wrapping and presentation.